Background:
Influenza (flu) virus causes 3 to 5 million cases of severe illness and up to 650,000 deaths per year worldwide. Current vaccines work well against single strains of flu virus. But no single vaccine works well against all flu viruses that can cause illness.
Objective:
To test an experimental flu vaccine (FluMos-v2) in healthy adults.
Eligibility:
Healthy adults aged 18 to 50 years.
Design:
Participants will have 11 clinic visits in 10 months. They must agree not to get a licensed flu vaccine while taking part in this study.
FluMos-v2 will be given with a needle injected into a muscle in the upper arm. Participants will receive a follow-up phone call the following day.
Participants will be given a diary card, a ruler, and a thermometer. They will take their temperature every day for 7 days after receiving the shot. They will measure any skin changes at the injection site. They will record their findings and how they feel.
Participants will receive a second FluMos-v2 shot after 4 months. They will repeat the other follow-up steps.
Participants will have 9 other clinic visits. Blood will be drawn at each visit.
Participants should also come to the clinic if they develop flu-like symptoms during the study.
Participants may opt for an apheresis 2 weeks after each shot: Blood will be removed through a needle in the vein of 1 arm. The blood will run through a machine that separates out the white blood cells. The remaining blood is returned through a needle in the other arm.
Source: View full study details on ClinicalTrials.gov
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. By listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
