Experimental: Treatment (tuvusertib, BET bromodomain inhibitor ZEN-3694)
Patients receive tuvusertib and BET bromodomain inhibitor ZEN-3694 PO on study. Patients in the dose-escalation phase of the trial also undergo ECG during screening, collection of blood samples on study, and x-ray, CT, or MRI throughout the trial. Patients in the dose-expansion phase of the trial also undergo ECG during screening, biopsies during screening and on study, and x-ray, CT, or MRI, and collection of blood samples throughout the trial.
Drug: BET Bromodomain Inhibitor ZEN-3694
Given PO
Other Names:
BETi ZEN-3694
ZEN 3694
ZEN-3694
ZEN003694
Procedure: Biopsy
Undergo biopsy
Other Names:
BIOPSY_TYPE
Bx
Procedure: Biospecimen Collection
Undergo collection of blood samples
Other Names:
Biological Sample Collection
Biospecimen Collected
Specimen Collection
Procedure: Computed Tomography
Undergo CT
Other Names:
CAT
CAT Scan
Computed Axial Tomography
Computerized Axial Tomography
Computerized axial tomography (procedure)
Computerized Tomography
CT
CT Scan
tomography
Procedure: Electrocardiography
Undergo ECG
Other Names:
Procedure: Magnetic Resonance Imaging
Undergo MRI
Other Names:
Magnetic Resonance
Magnetic resonance imaging (procedure)
Magnetic Resonance Imaging Scan
Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
MR
MR Imaging
MRI
MRI Scan
NMR Imaging
NMRI
Nuclear Magnetic Resonance Imaging
Drug: Tuvusertib
Given PO
Other Names:
ATR Kinase Inhibitor M1774
M 1774
M-1774
M1774
Procedure: X-Ray Imaging
Undergo x-ray
Other Names:
Conventional X-Ray
Diagnostic Radiology
Medical Imaging, X-Ray
Plain film radiographs
Radiographic Imaging
Radiographic imaging procedure (procedure)
Radiography
RG
Static X-Ray
X-Ray
Source: View full study details on ClinicalTrials.gov
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