Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas

Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade Gliomas
Conditions: MGMT-unmethylated Glioblastoma (GBM); IDH Wildtype Glioblastoma

Interventions: Drug: avutometinib and defactinib for 3 weeks on/1 week off; Drug: MGMT-unmethylated GBM with Radiation

Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Keep Punching Foundation

Not yet **RECRUITING NOW**

Source: View full study details on ClinicalTrials.gov

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August 22, 2026Comments OffClinicalTrials.gov | Oncology Clinical Trials | Oncology Studies | US National Library of Medicine
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