Experimental: ALX148 + Doxorubicin (PLD) + Pembrolizumab
Given on Day 1 of each 21 day cycle, in the following order of administration:
200 mg IV pembrolizumab* (maximum of 2 years (approximately 35 cycles)
45 mg/kg IV ALX148
30 mg/m^2 IV doxorubicin (Pegylated Liposomal Doxorubicin (PLD)*
*standard of care
Drug: Pembrolizumab
A type of immunotherapy that stimulates the body’s immune system to fight cancer cells by targeting and blocking PD-1 proteins on the surface of certain immune T-cells, thus triggering the T-cells to find and kill cancer cells.
Other Name: Keytruda®
Drug: ALX148
A fusion protein comprised of a high affinity CD47 blocker linked to an inactive immunoglobulin Fc region, enhancing innate and adaptive immune responses against cancer.
Other Name: evorpacept
Drug: Doxorubicin
An anthracycline that slows/stops the growth of cancer cells by blocking an enzyme called topo isomerase 2, used as second line non-platinum chemotherapy in patients with platinum-resistant ovarian cancer.
Other Name: (Pegylated Liposomal Doxorubicin (PLD)
Source: View full study details on ClinicalTrials.gov
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