Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are:

Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function?
Does exposure to high glucose impair autophagy and subsequently microvascular function?

Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.

Source: View full study details on

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March 16, 2023Comments | Endocrinology Clinical Trials | Endocrinology Studies | US National Library of Medicine