I. Determine the proportion of benign nodules appearing as hot/warm on radioiodine scans (nodule uptake >= uptake in normal thyroid tissues).
II. To identify a possible relationship between iodine-123 (I-123) uptake on planar and single-photon emission computerized tomography (SPECT)/computerized tomography (CT) images and malignancy on surgical pathology in thyroid nodules which were previously identified by fine-needle aspiration (FNA) as indeterminate follicular neoplasms.
III. Examine correlations between intensity of uptake in follicular nodules before surgery (standard uptake values [SUV] on the quantitative reconstructions from our Veriton SPECT/CT scanner and nodule-to-normal thyroid background ratios on planar and SPECT images) and pathology findings and determine an SUV threshold that best distinguishes between benign and malignant nodules.
IV. Compare the usefulness of conventional planar imaging versus SPECT/CT imaging for thyroid nodules, in order to inform our optimal clinical protocol.
V. Establish an imaging protocol best suited for measuring uptake in small thyroid nodules.
Patients receive iodine-123 orally (PO) and then undergo planar imaging and a SPECT/CT scan on study.
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