Open Label Extension of Efgartigimod in Adults With Post-COVID-19 POTS

Open Label Extension of Efgartigimod in Adults With Post-COVID-19 POTS

Brief Summary:
The OLE study aims to investigate the safety, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod in participants with post-COVID-19 postural orthostatic.

Condition or disease

Post-COVID Postural Orthostatic Tachycardia Syndrome Postural Orthostatic Tachycardia Syndrome
Drug: Efgartigimod
Phase 2

Detailed Description:
Study ARGX-113-2105 is a long-term, single-arm, open-label, multicenter extension of the ARGX-113-2104 study, designed to evaluate the long-term safety of efgartigimod IV in adult patients with PC-POTS. Participants will be enrolled from both active and placebo arms of the ARGX-113-2104 study and will receive efgartigimod IV 10 mg/kg in the extension study without knowledge of their prior treatment arm. To be eligible to enroll in this study, participants must have completed the 24-week treatment period of the ARGX-113-2104 study and must not have permanently discontinued the IMP in that study.

Source: View full study details on

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June 27, 2023Comments OffCardiology | Cardiology Clinical Trials | Cardiology Studies | | Drug Trials Near Me | US National Library of Medicine