Itraconazole to Prevent Recurrent Barrett’s Esophagus

Itraconazole to Prevent Recurrent Barrett’s Esophagus

Brief Summary:

Recurrent Barrett’s esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE. Over time, after eradication, BE ultimately recurs in as many as 30-50% of the patients putting them at risk for esophageal adenocarcinoma (EAC), thereby undoing the benefits of an effective initial therapy. Also, recurrences need retreatments that increase costs and complications including strictures and refractory ulcerations. A therapy to prevent recurrent BE does not currently exist. Itraconazole with its ability to inhibit important molecular pathways related to BE development could enhance the long-term effectiveness of endoscopic eradication of high-risk BE, thereby promoting a long-term cure

Condition or disease Intervention/treatment Phase
Barrett Oesophagitis With DysplasiaDrug: Itraconazole in capsule form Drug: Itraconazole in solution formPhase 1

Source: View full study details on

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. By listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.

November 10, 2022Comments | Oncology Clinical Trials | Oncology Studies | US National Library of Medicine