Ativan is an anti-anxiety medication used to treat panic attacks, neurosis-like conditions, and various disorders caused by stress.
Indications and dosage
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According to Ativan instruction, it should be used when:
Sleep disorders that are caused by anxiety or short-term stressful situations
Epilepsy and status epilepticus, most often as part of combination therapy
Psychoreactive states and phobias
Emotional reactive states
Psychosomatic disorders and headaches with respiratory, gastrointestinal, cardiovascular and other diseases of the internal organs
Endogenous psychoses, including manic and catatonic conditions, as well as states of anxiety and agitation in schizophrenia
Acute alcohol delirium
Neuroses and neurosis-like conditions
Symptomatic Seizure Conditions
Ativan is taken orally, 1 mg 2-3 times a day. To improve falling asleep – 1-2 mg 30 minutes before bedtime. With a pronounced state of anxiety and arousal, the dose should be increased to 4-6 mg/day (no more). For sedation, it is prescribed 1 hour before the operation, for adults – 2.5-5 mg, for children – 0.05 mg / kg. Cancellation should occur gradually due to the risk of the convulsive syndrome. In elderly and debilitated patients, the dose should not exceed 2 mg/day. The duration of the initial course is not more than 1 week. In patients with renal or hepatic insufficiency, lower doses are used.
Ativan rarely causes side effects and, judging by the reviews, drug therapy is usually well tolerated.
The most common side effects include violations:
The central nervous system, in the form of increased fatigue, muscle weakness, ataxia, dizziness, amnesia.
Digestive system manifested as constipation, dry mouth, nausea, impaired appetite and liver function, dysphagia, diarrhea.
Also, the use of Ativan can lead to changes in the picture of peripheral blood and cause minor allergic reactions in the form of itching and skin rash.
Among the most likely local reactions with intravenous administration, according to reviews, are venous thrombosis and phlebitis. Most often, unwanted side effects with Ativan therapy are observed at the beginning of treatment or when the recommended doses of the drug are exceeded.
Contraindications to the use of lorazepam according to the instructions are:
Acute alcohol intoxication
Acute intoxication with psychotropic drugs
Hypersensitivity to lorazepam or other components of the drug
Ativan in any dosage form should not be used during pregnancy, especially in the first trimester, and during breastfeeding. The drug in the form of tablets is prescribed from 12 years old, in the form of a solution for injection – from 18 years old.
In addition, Ativan should be used with caution when:
Suspected angle-closure glaucoma and sleep apnea
Impaired renal function
Organic Brain Diseases
Severe Chronic Obstructive Pulmonary Disease
Interaction with other medicines and alcohol
Ativan enhances the effect of drugs that have a depressing effect on the central nervous system. Scopolamine enhances sedation, induces hallucinations, and illogical behavior. Cimetidine, estrogen contraceptives for oral administration, disulfiram, and erythromycin, inhibiting the oxidative conversion of benzodiazepines, to a lesser extent, affect the biotransformation of lorazepam, which is bound by glucuronides. Probenecid may interfere with the glucuronide binding of lorazepam, which leads to an increase in its concentration in plasma and, due to the enhancement of the therapeutic effect, the development of an excessive sedative effect.