Interventions: Drug: THR-149 dose level 1; Drug: THR-149 dose level 2; Drug: THR-149 dose level 3; Drug: THR-149 0.13mg; Drug: THR-149 0.13mg + aflibercept 2mg; Drug: aflibercept 2mg + THR-149 0.13mg; Drug: Aflibercept 2mg
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