This is a first-in-human, Phase 1/2 open-label, multi-center, dose escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with advanced solid tumors.
This study is being conducted in three parts:
- Part A: Phase 1 Monotherapy Dose Escalation (SNS-101 alone)
- Part B: Phase 1 Combination Dose Escalation (SNS-101 in combination with cemiplimab)
- Part C: Phase 2 Expansion Cohorts (SNS-101 alone or in combination with cemiplimab)
Source: View full study details on ClinicalTrials.gov
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